Blar i forfatter "Verlhac, Pauline"

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    • ATG9A protects the plasma membrane from programmed and incidental permeabilization. 

      Claude-Taupin, Aurore; Jia, Jingyue; Bhujabal, Zambarlal; Garfa-Traore, Meriem; Kumar, Suresh; da Silva, Gustavo Peixoto Duarte; Javed, Ruheena; Gu, Yuexi; Allers, Lee; Peters, Ryan; Wang, Fulong; da Costa, Luciana Jesus; Pallikkuth, Sandeep; Lidke, Keith A; Mauthe, Mario; Verlhac, Pauline; Uchiyama, Yasuo; Salemi, Michelle; Phinney, Brett; Tooze, Sharon A; Mari, Muriel C.; Johansen, Terje; Reggiori, Fulvio; Deretic, Vojo (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-12)
      The integral membrane protein ATG9A plays a key role in autophagy. It displays a broad intracellular distribution and is present in numerous compartments, including the plasma membrane (PM). The reasons for the distribution of ATG9A to the PM and its role at the PM are not understood. Here, we show that ATG9A organizes, in concert with IQGAP1, components of the ESCRT system and uncover cooperation ...

    • SQSTM-1/p62 potentiates HTLV-1 Tax-mediated NF-κB activation through its ubiquitin binding function 

      Schwob, Aurélien; Teruel, Elodie; Dubuisson, Louise; Lormières, Florence; Verlhac, Pauline; Abudu, Yakubu Princely; Gauthier, Janelle; Naoumenko, Marie; Cloarec-Ung, Fanny-Meï; Faure, Mathias; Johansen, Terje; Dutartre, Hélène; Mahieux, Renaud; Journo, Chloé (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-05)
      The NF-κB pathway is constitutively activated in adult T cell leukemia, an aggressive malignancy caused by Human T Leukemia Virus type 1 (HTLV-1). The viral oncoprotein Tax triggers this constitutive activation by interacting with the ubiquitin-rich IKK complex. We previously demonstrated that Optineurin and TAX1BP1, two members of the ubiquitin-binding, Sequestosome-1 (SQSTM-1/p62)-like selective ...

    • TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1 

      Zhou, Jianwen; Rasmussen, Nikoline Lander; Olsvik, Hallvard Lauritz; Akimov, Vyacheslav; Hu, Zehan; Evjen, Gry; Kaeser-Pebernard, Stéphanie; Sankar, Devanarayanan Siva; Roubaty, Carole; Verlhac, Pauline; van de Beck, Nicole; Reggiori, Fulvio; Abudu, Yakubu Princely; Blagoev, Blagoy; Lamark, Trond; Johansen, Terje; Dengjel, Jörn (Journal article; Tidsskriftartikkel, 2022-12-27)
      Limitation of excessive inflammation due to selective degradation of pro-inflammatory proteins is one of the cytoprotective functions attributed to autophagy. In the current study, we highlight that selective autophagy also plays a vital role in promoting the establishment of a robust inflammatory response. Under inflammatory conditions, here TLR3-activation by poly(I:C) treatment, the inflammation ...